.The ABCs of CBD

Prayer, meditation and eating chocolate are three ways to increase levels of anandamide—one of the body’s endogenous (that is, manufactured in the brain) cannabinoids, or endocannabinoids. I start with anandamide because, for one, it is known as the “bliss molecule”—its name derived from the Sanskrit for “inner bliss.” Acting similarly to THC and CBD (cannabidiol)—two of more than 150 cannabinoids found in the cannabis plant—it dulls pain, and helps us to quickly forget it. It’s responsible for runner’s high, for instance. I also begin with this molecule because its discovery in 1992—by Raphael Mechoulam of Israel, 30 years after he discovered THC—helped shed light on the body’s endocannabinoid system, or ECS.

The ECS acts as a homeostatic buffer, and helps to keep our neurotransmitter levels in proper balance. In the words of Michael Pollan in Botany of Desire, it seems to exist as a natural curative for the “routine slings and arrows of life.” It does this via cannabinoid receptors found throughout the body—predominantly in the brain, central nervous system and the immune system.

“Just to put it into perspective,” says local chiropractor Dr. Michelle Bean, “we don’t have receptors on our brain that directly bind Vitamin B. Or Omega 3s.” There is no other known plant extract, she says, that can directly bind receptors on the brain and have an immediate and direct influence on the brain and central nervous system.

But if our bodies are already equipped with their own natural endocannabinoids, why should we need the aid of a plant’s cannabinoids? This is one of many questions addressed by Bean and LeTa Jussila, licensed acupuncturist and herbalist, in their free weekly classes about CBD.

One answer is that our ECSs are being compromised by depleted diets, environmental toxins and stress. Too often these days, we’re living stressed-out lifestyles, says Bean. “It’s like having one foot on the gas and one foot on the brake. We are not designed to do that. The fight-or-flight system in our body is designed to be used quickly, and then come back to rest. The sympathetic nervous system and the immune system do not operate at the same time.”

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Ethan Russo, M.D. has been studying CBD for two decades, and in 2001 introduced the concept of clinical endocannabinoid deficiency. “If you don’t have enough endocannabinoids, you have pain where there shouldn’t be pain,” said Russo in a recent interview with Project CBD. “… a number of very common diseases seem to fit a pattern that would be consistent with an endocannabinoid deficiency; specifically these are migraine, irritable bowel syndrome, and fibromyalgia.”

In other words, explains Bean, “When we don’t have a healthy endocannabinoid tone, our pain threshold starts to diminish. So stimuli that would typically not induce pain or disease starts to induce pain and disease.”

One of CBD’s many benefits to the human system is that it slows the breakdown of anandamide, extending the bliss molecule’s effects. It also ignites pathways of arachidonoylglycerol, or 2ag, another endocannabinoid responsible for modulating many systems—including shutting down inflammatory processes in the body, a leading cause of disease, says Bean.

A 2012 study published in the British Journal of Pharmacology found that CBD altered the expression of genes, upregulating 680 gene probe sets and down-regulating 524 to help the liver and body’s systems detoxify, and countering inflammation.

Bean and Jussila began their research of CBD after Bean saw it change her mother’s life. After three spinal surgeries—the last of which left her with a fused spine and a cocktail of painkillers, her mother was in constant pain. “I stayed away from CBD and cannabis for the longest time, because I always thought of it as a drug. Then they added the word ‘medical’ to marijuana, and that got my attention,” says Bean. “Within two days of administering different types of CBD and THC, her pain dropped from a chronic 15-year cycle of 10-plus to about a six. At the end of the week, she dropped down to a zero,” says Bean. It helped her to cut down considerably on pharmaceutical painkillers.

The list of ailments that CBD is showing promise in helping is long, and in addition to mitigating pain, includes help with seizures, Parkinson’s disease, brain inflammation, depression, anxiety, sleep and mood disorders, and inhibiting growth of cancerous tumors.

As CBD becomes widely available at health food stores, Bean cautions consumers to choose organically-sourced, non-GMO products. She also raises a point that is all too relevant to medicinal plants in the face of big pharma: “We have to know, especially in countries like ours that are so reductionist, that the cannabis plant has more than 150 cannabinoids for a reason—terpenes and flavonoids that work synergistically. The fear is we’re going to start extracting just the CBD, synthesizing it in labs, and giving it in pill form to people. It’s already happening with two pharmaceutical companies.”

For more information on CBD classes at Santa Cruz Chi Center, visit facebook.com/pg/SantaCruzBootCamp/events.



  1. My husband is 80 years and has been suffering from PD for the past 15 years. Lately he started hallucinating and I didn’t know how to handle the situation. He cannot sleep and tried to find and catch the imaginary people who he thinks are real. he was taken Entacapone with Levodopa, Carbidopa, and Pramipexole and started physical therapy to strengthen muscles. nothing was really working to help his condition.I took him off the Siferol (with the doctor’s knowledge) and started him on parkinson’s herbal formula i ordered from Health Herbal Clinic, his symptoms totally declined over a 5 weeks use of the Parkinsons disease natural herbal formula.i read reviews from other previous patients who used the herbal formula, my husband is now active, he can now go about daily exercise!! his symptoms so much reduced that now I hardly notice them.

  2. I would reframe the question, Why should “we” need the aid of a plant’s cannabinoids? as, Why do some of us need them? And to answer it, I would focus on the concept of endocannabinoid deficiency. In my 50+ years of cannabis use, I’ve noticed that many people who try it don’t like it; I’d say on the order of 75%. That has always led me to believe that people vary significantly in their innate neurochemistry, at least in respect of their need for cannabinoids, and since I heard about Mechoulam’s 1992 discovery of endocannabinoids I’ve been sure of it. I propose more attention to a possible congenital endocannabinoid deficiency in a subgroup of the population that may not rise to Dr Russo’s “clinical” level but causes chronic if subtle mental dysfunction (dis-ease, unease) that is relieved by supplemental plant cannabinoids. At least that’s always been my answer to why I need cannabis.
    By the way, don’t extracts from the opium poppy also “directly bind receptors on the brain and have an immediate and direct influence on the brain and central nervous system”? The endorphin system is a close analog to the endocannabinoid system—both were discovered by looking for the receptors that the respective plant-extract “drugs” bind to—the difference being that supplemental opiates can create dependency by suppressing the endorphin system when they bind to its receptors, but there’s nothing better to deal with acute pain that endorphins can’t handle. There’s a reason that both Cannabis and Papaver somniferum were among the earliest plants to be domesticated, and we have selectively bred them for many millennia for their precise fit with our neuro-receptors.


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